Retatrutide for Lean Bulking: A Comprehensive Guide for Bodybuilders

1. Dosing Strategy

Retatrutide’s appetite-suppressing effects can be powerful, so dosing must be strategic during bulking:

• Start Low: Begin with 0.2–0.6 mg/day to gently regulate appetite without suppressing it entirely.

• Titrate Based on Response: If appetite is too low, reduce to 0.25–0.5 mg every other day.

• Goal: Maintain enough hunger to support a calorie surplus, while benefiting from Retatrutide’s nutrient partitioning and fat oxidation effects.

• Timing: Consider taking it in the evening to reduce late-night cravings without affecting daytime meal intake.

2. Nutrition Tips

To build muscle while minimising fat gain, nutrition must be dialled in:

✅ Macronutrient Targets

• Protein: Aim for 1.6–2.2 g/kg/day to support muscle protein synthesis.

• Carbohydrates: Include complex carbs (e.g., oats, rice, sweet potatoes) to fuel training and recovery.

• Fats: Healthy fats (e.g., olive oil, nuts, avocado) support hormone production and satiety.

✅ Meal Frequency

• Eat 4–6 meals per day to ensure consistent nutrient delivery.

• Use liquid meals or shakes if appetite is low due to Retatrutide.

✅ Supplements

• Essential Amino Acids (EAAs) or Branched-Chain Amino Acids (BCAAs) pre/post workout.

• Creatine monohydrate for strength and lean mass.

• Electrolytes to support hydration and muscle function.

3. Training Recommendations

Retatrutide doesn’t build muscle directly—it supports the metabolic environment. Training is key:

🧠 Training Principles

• Progressive Overload: Increase weights, reps, or intensity weekly.

• Compound Movements: Prioritise squats, deadlifts, bench press, rows, and overhead press.

• Volume & Frequency: Train each muscle group 2–3 times per week with 8–20 sets per week.

💤 Recovery

• Sleep: Aim for 7–9 hours/night.

• Rest Days: Include 1–2 rest days/week or active recovery sessions.

4. Safety Considerations

Retatrutide is still under clinical investigation, so caution is essential:

• Medical Supervision: Consult a healthcare provider before starting, especially if you have diabetes, thyroid issues, or metabolic conditions.

• Monitor Body Composition: Use DEXA scans, calipers, or smart scales to track lean mass vs fat mass.

• Hydration: Appetite suppression can reduce fluid intake—drink 3–4 litres/day.

• Electrolyte Balance: Supplement with magnesium, potassium, and sodium if needed.

⚠️ Common Mistakes to Avoid

• Overdosing: High doses can kill appetite and hinder bulking.

• Under-eating: Even with Retatrutide, you must eat enough to grow.

• Neglecting Training: Without resistance training, Retatrutide may lead to lean mass loss.

✅ Summary

Retatrutide can be a powerful tool for lean bulking when used correctly:

• Helps minimise fat gain during a calorie surplus.

• Improves nutrient partitioning and insulin sensitivity.

• Supports fat oxidation and metabolic health.

• Must be paired with smart dosing, structured nutrition, and progressive training.